2. Academic Validation
  3. Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia

Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia

  • Sci Rep. 2021 Apr 28;11(1):9182. doi: 10.1038/s41598-021-88463-6.
So-Young Oh # 1 2,  Min Jun Jang # 1,  Yun-Hyeok Choi 3,  Hongik Hwang 1,  Hyewhon Rhim 1 4,  Bonggi Lee 5,  Chun Whan Choi 6,  Min Soo Kim 7 8
Affiliations

Affiliations

  • 1 Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
  • 2 Infectious Disease Research Center, Citizen's Health Bureau, Seoul Metropolitan Government, 110, Sejong-daero, Jung-gu, Seoul, 04524, Republic of Korea.
  • 3 Natural Product Research Team, Gyeonggi Biocenter, Gyeonggido Business and Science Accelerator, Gyeonggi-Do, Republic of Korea.
  • 4 Division of Bio-Medical Science & Technology, University of Science and Technology KIST School, Seoul, Republic of Korea.
  • 5 Department of Food Science and Nutrition, Pukyong National University, Busan, Republic of Korea.
  • 6 Natural Product Research Team, Gyeonggi Biocenter, Gyeonggido Business and Science Accelerator, Gyeonggi-Do, Republic of Korea. cwchoi78@gmail.com.
  • 7 Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea. minsoo.kim@kist.re.kr.
  • 8 Division of Bio-Medical Science & Technology, University of Science and Technology KIST School, Seoul, Republic of Korea. minsoo.kim@kist.re.kr.
  • # Contributed equally.
PMID: 33911138 DOI: 10.1038/s41598-021-88463-6
Abstract

Neurodegenerative disorders are characterized by the decline of cognitive function and the progressive loss of memory. The dysfunctions of the cognitive and memory system are closely related to the decreases in brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) signalings. Ribes fasciculatum, a medicinal plant grown in diverse countries, has been reported to pharmacological effects for autoimmune diseases and aging recently. Here we found that afzelin is a major compound in Ribes fasciculatum. To further examine its neuroprotective effect, the afzelin (100 ng/µl, three times a week) was administered into the third ventricle of the hypothalamus of C57BL/6 mice for one month and scopolamine was injected (i.p.) to these mice to impair cognition and memory before each behavior experiment. The electrophysiology to measure long-term potentiation and behavior tests for cognitive and memory functions were performed followed by investigating related molecular signaling pathways. Chronic administration of afzelin into the brain ameliorated synaptic plasticity and cognitive/memory behaviors in mice given scopolamine. Studies of mice's hippocampi revealed that the response of afzelin was accountable for the restoration of the cholinergic systems and molecular signal transduction via CREB-BDNF pathways. In conclusion, the central administration of afzelin leads to improved neurocognitive and neuroprotective effects on synaptic plasticity and behaviors partly through the increase in CREB-BDNF signaling.

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