Regulating Twisted Skeleton to Construct Organ-Specific Perylene for Intensive Cancer Chemotherapy

The systemic use of pharmaceutical drugs for Cancer patients is a compromise between desirable therapy and side effects because of the intrinsic shortage of organ-specific pharmaceutical drug. Design and construction of pharmaceutical drug to achieve the organ-specific delivery is thus desperately desirable. We herein regulate perylene skeleton to effect organ-specificity and present an example of lung-specific distribution on the basis of bay-twisted PDIC-NC. We further demonstrate that PDIC-NC can target into mitochondria to act as cellular respiration inhibitor, inducing insufficient production of adenosine triphosphate, promoting endogenous H₂ O₂ and ^. OH burst, elevating calcium overload, efficiently triggering the synergistic Apoptosis, Autophagy and endoplasmic reticulum stress of lung Cancer cells. The antitumor performance of PDIC-NC is verified on in vivo xenografted, metastasis and orthotopic lung Cancer, presenting overwhelming evidences for potentially clinical application. This study contributes a proof-of-concept demonstration of twisted perylene to well attain lung-specific distribution, and meanwhile achieves intensive lung Cancer chemotherapy.

chemotherapy; fluorescence image; molecular mechanism; perylene; twisted skeleton.