2. Academic Validation
  3. Iridoid Constituents of Viburnum brachybotryum

Iridoid Constituents of Viburnum brachybotryum

  • J Nat Prod. 2021 Jul 23;84(7):1915-1923. doi: 10.1021/acs.jnatprod.1c00042.
Li Rao 1,  Yao Li 2,  Qian He 1,  Yu Liu 1,  Yu Su 1,  Yun-Xia You 1,  Yue Fan 1,  Bin Lin 3,  Yi-Nan Zhang 2,  Chuan-Rui Zhang 1 4
Affiliations

Affiliations

  • 1 Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, People's Republic of China.
  • 2 Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China.
  • 3 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
  • 4 Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
PMID: 34165979 DOI: 10.1021/acs.jnatprod.1c00042
Abstract

Eleven new Iridoids, brachybones A-K (1-11), were isolated from the twigs of Viburnum brachybotryum. Their structures including absolute configurations were determined by spectroscopic data analysis and from the electronic circular dichroism (ECD) spectra. All of the compounds 1-11 possess one or two acetoxysenecioate substituents. Furthermore, compounds 5-7 and 11 feature a Cl atom in the molecule, while compounds 9-11 exhibit a cagelike rigid skeleton through an unusual oxo bridge from C-3 to C-8 or C-10. The isolates were evaluated for cytotoxic activity against the HCT-116, A549, and Hela cell lines, and the results showed compounds 10 and 11 to be active against HCT-116 cells.

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