2. Academic Validation
  3. Goldenrod Root Compounds Active against Crop Pathogenic Fungi

Goldenrod Root Compounds Active against Crop Pathogenic Fungi

  • J Agric Food Chem. 2021 Nov 3;69(43):12686-12694. doi: 10.1021/acs.jafc.1c03676.
Dániel Krüzselyi 1,  József Bakonyi 1,  Péter G Ott 1,  András Darcsi 2,  Péter Csontos 3,  Gertrud E Morlock 4,  Ágnes M Móricz 1
Affiliations

Affiliations

  • 1 Plant Protection Institute, Centre for Agricultural Research, Eötvös Loránd Research Network (ELKH), Herman Ottó Street 15, 1022 Budapest, Hungary.
  • 2 Pharmaceutical Chemistry and Technology Department, National Institute of Pharmacy and Nutrition, Zrínyi Street 3, 1051 Budapest, Hungary.
  • 3 Institute for Soil Sciences, Centre for Agricultural Research, Eötvös Loránd Research Network (ELKH), Herman Ottó Street 15, 1022 Budapest, Hungary.
  • 4 Chair of Food Science, Institute of Nutritional Science, and TransMIT Center of Effect-Directed Analysis, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.
PMID: 34665636 DOI: 10.1021/acs.jafc.1c03676
Abstract

Root extracts of three goldenrods were screened for antimicrobial compounds. 2Z,8Z- and 2E,8Z-matricaria esters from European goldenrod (Solidago virgaurea) and E- and Z-dehydromatricaria esters from grass-leaved goldenrod (Solidago graminifolia) and first from showy goldenrod (Solidago speciosa) were identified by high-performance thin-layer chromatography combined with effect-directed analysis and high-resolution mass spectrometry or nuclear magnetic resonance spectroscopy after liquid chromatographic fractionation and isolation. Next to their Antibacterial effects (against Bacillus subtilis, Aliivibrio fischeri, and Pseudomonas syringae pv. maculicola), they inhibited the crop pathogenic fungi Fusarium avenaceum and Bipolaris sorokiniana with half maximal inhibitory concentrations (IC50) between 31 and 107 μg/mL. Benzyl 2-hydroxy-6-methoxybenzoate, for the first time found in showy goldenrod root, showed the strongest Antifungal effect, with IC50 of 25-26 μg/mL for both Fungal strains.

Keywords

Bipolaris sorokiniana; Fusarium avenaceum; HPTLC−EDA; Solidago species; antifungal assay.

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