2. Academic Validation
  3. Sublyratins A-O, Labdane-Type Diterpenoids from Croton sublyratus

Sublyratins A-O, Labdane-Type Diterpenoids from Croton sublyratus

  • J Nat Prod. 2021 Nov 26;84(11):2971-2980. doi: 10.1021/acs.jnatprod.1c00804.
Jing-Jing Qi 1 2,  Jun-Su Zhou 1,  Yan Zhang 1,  Yao-Yue Fan 1,  Bin Zhou 1,  Hong-Chun Liu 1,  Jin-Xin Zhao 1,  Jian-Min Yue 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
  • 2 School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, People's Republic of China.
PMID: 34762434 DOI: 10.1021/acs.jnatprod.1c00804
Abstract

Fifteen new labdane-type Diterpenoids, sublyratins A-O (1-15), along with four known analogues (16-19) were isolated from the aerial parts of Croton sublyratus. Their structural assignments were challenging due to the stereoisomeric features evident and were achieved by analyzing comprehensively the spectroscopic data and electronic circular dichroism spectra and using X-ray crystallographic analysis. Compounds 9 and 16-18 displayed cytotoxic activity against the HL-60 cell line with IC50 values of 1.5-2.8 μM.

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