[Restatment. Anal Cancer]

ANAL Cancer Anal Cancer, a rare disease, had increased annual incidence in the recent decades due to high prevalence of HPV. Squamous cell carcinoma is the most frequent histological type and pelvic lymph node invasion is common. However metastatic progression remains unfrequent. Chemoradiotherapy (CRT) is the current standard of care achieving a good loco-regional control, whereas salvage surgery can be proposed in case of treatment failure or local relapse. Better oncological results have been seen given the technological advances in radiotherapy and radiology, whereas chemotherapy has not been modified for 40 years. Personnalized strategies taking into account tumoral staging and patient characteristics as well as immunotherapy are being investigated in current trials. Finally, major advances could come from HPV vaccination.

Anus Neoplasms.