2. Academic Validation
  3. Cyantraniliprole impairs reproductive parameters by inducing oxidative stress in adult female wistar rats

Cyantraniliprole impairs reproductive parameters by inducing oxidative stress in adult female wistar rats

  • Reprod Toxicol. 2022 Jan:107:166-174. doi: 10.1016/j.reprotox.2021.12.009.
Suellen Ribeiro da Silva Scarton 1,  Felipe Tsuzuki 2,  Marina Trevizan Guerra 3,  Dayane Priscila Dos Santos 4,  Aldair Casagrande Dos Santos 5,  Ana Tereza Bittencourt Guimarães 6,  Andréa Name Colado Simão 7,  Célia Cristina Leme Beu 8,  Glaura Scantamburlo Alves Fernades 9
Affiliations

Affiliations

  • 1 Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Rodovia Celso Garcia Cid, PR 445, 86057-970, Londrina, Parana, Brazil; Department of General Pathology, Biological Sciences Center, State University of Londrina - UEL, Rodovia Celso Garcia Cid, PR 445, 86057-970, Londrina, Parana, Brazil. Electronic address: suellen.scarton@uel.br.
  • 2 Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Rodovia Celso Garcia Cid, PR 445, 86057-970, Londrina, Parana, Brazil. Electronic address: felipe.tsuzuki@outlook.com.
  • 3 Federal University of Mato Grosso do Sul, Campus Três Lagoas, 3484 Ranulpho Marques Leal Avenue, 79613-000, Três Lagoas, Mato Grosso do Sul, Brazil. Electronic address: marinatguerra@gmail.com.
  • 4 Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Rodovia Celso Garcia Cid, PR 445, 86057-970, Londrina, Parana, Brazil; Department of General Pathology, Biological Sciences Center, State University of Londrina - UEL, Rodovia Celso Garcia Cid, PR 445, 86057-970, Londrina, Parana, Brazil. Electronic address: daayane.ps@gmail.com.
  • 5 Medical and Pharmaceutical Sciences Center, State University of Western Paraná - UNIOESTE, Universitária Street, 1619, PR, 85819-110, Cascavel, Paraná, Brazil. Electronic address: aldaircasagrande1@hotmail.com.
  • 6 Medical and Pharmaceutical Sciences Center, State University of Western Paraná - UNIOESTE, Universitária Street, 1619, PR, 85819-110, Cascavel, Paraná, Brazil. Electronic address: anatbguimaraes@gmail.com.
  • 7 Department of General Pathology, Biological Sciences Center, State University of Londrina - UEL, Rodovia Celso Garcia Cid, PR 445, 86057-970, Londrina, Parana, Brazil. Electronic address: deianame@gmail.com.
  • 8 Medical and Pharmaceutical Sciences Center, State University of Western Paraná - UNIOESTE, Universitária Street, 1619, PR, 85819-110, Cascavel, Paraná, Brazil. Electronic address: celiabeu@yahoo.com.
  • 9 Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Rodovia Celso Garcia Cid, PR 445, 86057-970, Londrina, Parana, Brazil. Electronic address: glaura@uel.br.
PMID: 34968715 DOI: 10.1016/j.reprotox.2021.12.009
Abstract

Cyantraniliprole is a synthetic insecticide used to control pests of up to 23 different types of crops. It is able to modulate ryanodine-like calcium channels, which are widely found in the organism of insects and mammals. The objective of this research was to verify the possible reproductive effects of adult female Wistar rats exposure to cyantraniliprole. Animals (67 days old) were exposed to the chemical at doses of 10 or 150 mg/kg/day, orally, for 28 consecutive days (control Animals received only the vehicle). Vaginal secretions were collected during the exposure period to assess the regularity of the estrous cycle; the liver, kidneys, pituitary gland, adrenal gland, uterus, and ovaries were collected and weighed; reproductive organs were assessed for histopathological evaluation and for biochemical markers of oxidative stress and progesterone plasma level was measured. Both doses caused negative changes in the morphology and redox system of the uterus and ovaries. Animals exposed to 10 mg/kg also exhibited higher level of plasma progesterone, elevated levels of lipid peroxidation in reproductive organs, increased superoxide dismutase activity in the uterus and Glutathione Peroxidase activity on the ovary, while the 150 mg/kg group exhibited an increment in estrous cycle length and diminished uterine glandular epithelium. Based on these results, we conclude that cyantraniliprole may have acted as an endocrine disruptor, and its effects are mediated by oxidative stress.

Keywords

Estrous cycle; Insecticide; Ovaries; Reproduction; Uterus.

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