2. Academic Validation
  3. Antibiotics from basidiomycetes. 26. Phlebiakauranol aldehyde an antifungal and cytotoxic metabolite from Punctularia atropurpurascens

Antibiotics from basidiomycetes. 26. Phlebiakauranol aldehyde an antifungal and cytotoxic metabolite from Punctularia atropurpurascens

  • J Antibiot (Tokyo). 1987 Apr;40(4):443-9. doi: 10.7164/antibiotics.40.443.
H Anke,  I Casser,  W Steglich,  E H Pommer
PMID: 3583914 DOI: 10.7164/antibiotics.40.443
Abstract

Phlebiakauranol aldehyde and the corresponding alcohol were isolated from cultures of Punctularia atropurpurascens. The aldehyde but not the alcohol exhibited strong Antifungal activity against several phytopathogens as well as Antibacterial and cytotoxic activities. Two acetylated derivatives prepared from the aldehyde showed only very weak Antifungal and Antibacterial and moderate cytotoxic activities. We therefore assume, that the aldehyde group together with the high number of hydroxyl groups are responsible for the biological activity of the compound.

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