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  3. Artificial Intelligence-Assisted Bioinformatics, Microneedle, and Diabetic Wound Healing: A "New Deal" of an Old Drug

Artificial Intelligence-Assisted Bioinformatics, Microneedle, and Diabetic Wound Healing: A "New Deal" of an Old Drug

  • ACS Appl Mater Interfaces. 2022 Aug 24;14(33):37396-37409. doi: 10.1021/acsami.2c08994.
Yanan Xue 1 2 3,  Cheng Chen 4,  Rong Tan 5,  Jingyu Zhang 1 2,  Qin Fang 1 2,  Rui Jin 1 2,  Xiangyu Mi 1 2,  Danying Sun 1 2,  Yinan Xue 6,  Yue Wang 1 2,  Rong Xiong 1 2,  Haojian Lu 1 2,  Weiqiang Tan 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Industrial Control and Technology, Zhejiang University, Hangzhou 310027, China.
  • 2 Institute of Cyber-Systems and Control, the Department of Control Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  • 3 Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University of Medicine, Hangzhou 310016, China.
  • 4 Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310000, China.
  • 5 Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, China.
  • 6 College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
PMID: 35913266 DOI: 10.1021/acsami.2c08994
Abstract

Diabetic wounds severely influence life, facing grand challenges in clinical treatments. The demand for better treatment is growing dramatically. Diabetic wound healing is challenging because of inflammation, angiogenesis disruptions, and tissue remodeling. Based on Sequencing results of diabetic patients' skins and artificial intelligence (AI)-assisted bioinformatics, we excavate a potential therapeutic agent Trichostatin A (TSA) and a potential target histone deacetylase 4 (HDAC4) for diabetic wound healing. The molecular docking simulation reveals the favorable interaction between TSA and HDAC4. Taking advantage of the microneedle (MN) minimally invasive way to pierce the skin barrier for drug administration, we develop a swelling modified MN-mediated patch loaded with TSA to reduce the probability of injection-caused iatrogenic secondary damage. The MN-mediated TSA patch has been demonstrated to reduce inflammation, promote tissue regeneration, and inhibit HDAC4, which provides superior results in diabetic wound healing. We envisage that our explored specific drug TSA and the related MN-mediated drug delivery system can provide an innovative approach for diabetic wound treatment with simple, effective, and safe features and find a broad spectrum of applications in related biomedical fields.

Keywords

Trichostatin A; artificial intelligence; bioinformatics; diabetic wounds; microneedle.

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