2. Academic Validation
  3. Neolignans and amide alkaloids from the stems of Piper kadsura and their neuroprotective activity

Neolignans and amide alkaloids from the stems of Piper kadsura and their neuroprotective activity

  • Phytochemistry. 2022 Nov;203:113336. doi: 10.1016/j.phytochem.2022.113336.
Hui Chen 1,  Ying Zhu 2,  Ya-Lun Zhang 2,  Meng-Nan Zeng 3,  Yan-Gang Cao 2,  Pan-Ting Sun 2,  Bing Cao 2,  Kun Du 2,  Xuan Zhao 2,  Xiao-Wei Wang 4,  Xiao-Ke Zheng 3,  Wei-Sheng Feng 5
Affiliations

Affiliations

  • 1 School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China; Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of PR China, Zhengzhou, 450046, PR China; NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine (Chinese Materia Medica and prepared slices), Zhengzhou, 450018, PR China. Electronic address: chenhuiyxy@hactcm.edu.cn.
  • 2 School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China.
  • 3 School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China; Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of PR China, Zhengzhou, 450046, PR China.
  • 4 NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine (Chinese Materia Medica and prepared slices), Zhengzhou, 450018, PR China. Electronic address: wxw0357@163.com.
  • 5 School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China; Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of PR China, Zhengzhou, 450046, PR China. Electronic address: fwsh@hactcm.edu.cn.
PMID: 35933005 DOI: 10.1016/j.phytochem.2022.113336
Abstract

Four undescribed neolignans and three undescribed amide Alkaloids, along with twelve known compounds, were isolated from the stems of Piper kadsura (Choisy) Ohwi. The structures of the new compounds were determined by spectroscopic analysis, quantum-chemical calculations, and Mo2(OAc)4-induced ECD analysis. The neuroprotective effects of these compounds against Aβ25-35-induced cell damage in PC12 cells were investigated, and eight compounds exhibited significant neuroprotective effects against Aβ25-35-induced PC12 cell damage, with the EC50 values of 3.06-29.3 μM. Three of these compounds were selected for further experiments, and they appear to reduce Apoptosis and enhance Autophagy against Aβ25-35-induced PC12 cell damage.

Keywords

Amide alkaloids; Autophagy; Neolignans; Neuroprotective activity; Piper kadsura (Choisy) ohwi; Piperaceae.

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