2. Academic Validation
  3. Effect of Pinoresinol and Vanillic Acid Isolated from Catalpa bignonioides on Mouse Myoblast Proliferation via the Akt/mTOR Signaling Pathway

Effect of Pinoresinol and Vanillic Acid Isolated from Catalpa bignonioides on Mouse Myoblast Proliferation via the Akt/mTOR Signaling Pathway

  • Molecules. 2022 Aug 24;27(17):5397. doi: 10.3390/molecules27175397.
Seo-Young Kim 1 2,  Sung-Pil Kwon 3 4,  SeonJu Park 1,  Su-Hyeon Cho 1,  Youngse Oh 5,  Seung Hyun Kim 5,  Yoon Ho Park 6,  Hyun Suk Jung 6,  Deug-Chan Lee 4,  Hoibin Jeong 1 7,  Kil-Nam Kim 1
Affiliations

Affiliations

  • 1 Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea.
  • 2 Honam National Institute of Biological Resources, Mokpo 58762, Korea.
  • 3 Research & Development Center, Chungdam CDC JNPharm LLC., Chuncheon 24341, Korea.
  • 4 Department of Biomedical Technology, Kangwon National University, Chuncheon 24341, Korea.
  • 5 Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea.
  • 6 Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 24341, Korea.
  • 7 Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 24341, Korea.
PMID: 36080161 DOI: 10.3390/molecules27175397
Abstract

Growth and maintenance of skeletal muscle is essential for athletic performance and a healthy life. Stimulating the proliferation and differentiation of muscle cells may help prevent loss of muscle mass. To discover effective natural substances enabling to mitigate muscle loss without side effects, we evaluated muscle growth with several compounds extracted from Catalpa bignonioides Walt. Among these compounds, pinoresinol and vanillic acid increased C2C12, a mouse myoblast cell line, proliferation being the most without cytotoxicity. These substances activated the Akt/mammalian target of the rapamycin (mTOR) pathway, which positively regulates the proliferation of muscle cells. In addition, the results of in silico molecular docking study showed that they may bind to the active site of insulin-like growth factor 1 receptor (IGF-1R), which is an upstream of the Akt/mTOR pathway, indicating that both pinoresinol and vanillic acid stimulate myoblast proliferation through direct interaction with IGF-1R. These results suggest that pinoresinol and vanillic acid may be a natural supplement to improve the proliferation of skeletal muscle via IGF-1R/Akt/mTOR signaling and thus strengthen muscles.

Keywords

Catalpa bignonioides; IGF-1 signaling; pinoresinol; vanillic acid.

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