2. Academic Validation
  3. Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells

Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells

  • Chem Commun (Camb). 2022 Nov 29;58(95):13250-13253. doi: 10.1039/d2cc05278d.
Ying Zhang 1,  Qianyu Zhang 2,  Zheng Chu 1,  Lin Chen 1,  Jiayun Chen 1,  Yang Yang 1,  Huan Tang 1,  Guangqing Cheng 1,  Ang Ma 1,  Ying Zhang 1,  Chen Wang 1,  Peng Gao 1,  Fei Xia 1,  Qiuyan Guo 1,  Qiaoli Shi 1,  Guang Han 2,  Jigang Wang 1 3,  Yinhua Zhu 1
Affiliations

Affiliations

  • 1 Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China. yhzhu@icmm.ac.cn.
  • 2 Pharmaceutical College, Henan University, Kaifeng, 75004, China. hang@henu.edu.cn.
  • 3 Department of Nephrology, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China.
PMID: 36367053 DOI: 10.1039/d2cc05278d
Abstract

Most of the known senolytics are anti-cancer drugs or their derivative molecules. However, senolytics derived from the active ingredients of traditional Chinese medicine (TCM) are rarely reported. Here, we identified oridonin as a novel senolytic and further revealed that it might target a class of glutathione S-transferases to activate ROS-p38 signaling and induce Apoptosis in senescent cells.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z