2. Academic Validation
  3. Ferroptosis MRI for early detection of anticancer drug-induced acute cardiac/kidney injuries

Ferroptosis MRI for early detection of anticancer drug-induced acute cardiac/kidney injuries

  • Sci Adv. 2023 Mar 10;9(10):eadd8539. doi: 10.1126/sciadv.add8539.
Fantian Zeng 1,  Sureya Nijiati 1,  Yangtengyu Liu 2,  Qinqin Yang 3,  Xiaomin Liu 1,  Qianyu Zhang 1,  Shi Chen 1,  Anqi Su 1,  Hehe Xiong 1,  Changrong Shi 1,  Congbo Cai 3,  Zhongning Lin 1,  Xiaoyuan Chen 4 5 6,  Zijian Zhou 1 7
Affiliations

Affiliations

  • 1 State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
  • 2 Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha 410008, China.
  • 3 Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen 361102, China.
  • 4 Departments of Diagnostic Radiology, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore 119074, Singapore.
  • 5 Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
  • 6 Nanomedicine Translational Research Programme, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
  • 7 Shenzhen Research Institute of Xiamen University, Shenzhen 518057, China.
PMID: 36888714 DOI: 10.1126/sciadv.add8539
Abstract

Ferroptosis has been realized in Anticancer drug-induced acute cardiac/kidney injuries (ACI/AKI); however, molecular imaging approach to detect Ferroptosis in ACI/AKI is a challenge. We report an artemisinin-based probe (Art-Gd) for contrast-enhanced magnetic resonance imaging of Ferroptosis (feMRI) by exploiting the redox-active Fe(II) as a vivid chemical target. In vivo, the Art-Gd probe showed great feasibility in early diagnosis of Anticancer drug-induced ACI/AKI, which was at least 24 and 48 hours earlier than the standard clinical assays for assessing ACI and AKI, respectively. Furthermore, the feMRI was able to provide imaging evidence for the different mechanisms of action of ferroptosis-targeted agents, either by blocking lipid peroxidation or depleting iron ions. This study presents a feMRI strategy with simple chemistry and robust efficacy for early evaluation of Anticancer drug-induced ACI/AKI, which may shed light on the theranostics of a variety of ferroptosis-related diseases.

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