2. Academic Validation
  3. A pan-influenza antibody inhibiting neuraminidase via receptor mimicry

A pan-influenza antibody inhibiting neuraminidase via receptor mimicry

  • Nature. 2023 May 31. doi: 10.1038/s41586-023-06136-y.
Corey Momont # 1,  Ha V Dang # 1,  Fabrizia Zatta # 2,  Kevin Hauser # 1,  Caihong Wang 3,  Julia di Iulio 1,  Andrea Minola 2,  Nadine Czudnochowski 1,  Anna De Marco 2,  Kaitlin Branch 1,  David Donermeyer 3,  Siddhant Vyas 1,  Alex Chen 1,  Elena Ferri 1,  Barbara Guarino 2,  Abigail E Powell 1,  Roberto Spreafico 1,  Samantha S Yim 1,  Dale R Balce 1,  Istvan Bartha 1,  Marcel Meury 1,  Tristan I Croll 4,  David M Belnap 5,  Michael A Schmid 2,  William Timothy Schaiff 3,  Jessica L Miller 1,  Elisabetta Cameroni 2,  Amalio Telenti 1,  Herbert W Virgin 1 6,  Laura E Rosen 1,  Lisa A Purcell 1,  Antonio Lanzavecchia 2,  Gyorgy Snell 7,  Davide Corti 8,  Matteo Samuele Pizzuto 9
Affiliations

Affiliations

  • 1 Vir Biotechnology, San Francisco, CA, USA.
  • 2 Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • 3 Vir Biotechnology, St. Louis, MO, USA.
  • 4 Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, Cambridge, UK.
  • 5 School of Biological Sciences, Department of Biochemistry, University of Utah, Salt Lake City, UT, USA.
  • 6 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  • 7 Vir Biotechnology, San Francisco, CA, USA. gsnell@vir.bio.
  • 8 Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland. dcorti@vir.bio.
  • 9 Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland. mpizzuto@vir.bio.
  • # Contributed equally.
PMID: 37258672 DOI: 10.1038/s41586-023-06136-y
Abstract

Rapidly evolving influenza A viruses (IAVs) and influenza B viruses (IBVs) are major causes of recurrent lower respiratory tract infections. Current influenza vaccines elicit Antibodies predominantly to the highly variable head region of haemagglutinin and their effectiveness is limited by viral drift1 and suboptimal immune responses2. Here we describe a neuraminidase-targeting monoclonal antibody, FNI9, that potently inhibits the enzymatic activity of all group 1 and group 2 IAVs, as well as Victoria/2/87-like, Yamagata/16/88-like and ancestral IBVs. FNI9 broadly neutralizes seasonal IAVs and IBVs, including the immune-evading H3N2 strains bearing an N-glycan at position 245, and shows synergistic activity when combined with anti-haemagglutinin stem-directed Antibodies. Structural analysis reveals that D107 in the FNI9 heavy chain complementarity-determinant region 3 mimics the interaction of the sialic acid carboxyl group with the three highly conserved arginine residues (R118, R292 and R371) of the neuraminidase catalytic site. FNI9 demonstrates potent prophylactic activity against lethal IAV and IBV infections in mice. The unprecedented breadth and potency of the FNI9 monoclonal antibody supports its development for the prevention of influenza illness by seasonal and pandemic viruses.

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