2. Academic Validation
  3. Anticancer evaluation of benzofuran derivatives linked to dipiperazine moiety

Anticancer evaluation of benzofuran derivatives linked to dipiperazine moiety

  • Bioorg Med Chem Lett. 2023 Jul 15;91:129378. doi: 10.1016/j.bmcl.2023.129378.
Yixin Liu 1,  Zhao Wu 1,  Minxin Li 1,  Hui Gao 1,  Chunping Wan 2,  Zewei Mao 3
Affiliations

Affiliations

  • 1 School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, PR China.
  • 2 Central Laboratory, The NO.1 Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650021, PR China. Electronic address: wanchunping1012@163.com.
  • 3 School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, PR China. Electronic address: maozw@ynutcm.edu.cn.
PMID: 37330115 DOI: 10.1016/j.bmcl.2023.129378
Abstract

In this work, a series of novel benzofuran derivatives linked to dipiperazine moiety have been prepared, and in vitro Anticancer activity against Hela and A549 was investigated. The results demonstrated that benzofuran derivatives exerted potent antitumor effect. Especially, compounds 8c and 8d showed better antitumor activity against A549 (IC50 = 0.12 μM and 0.43 μM). Further mechanism study indicated that compound 8d could significantly induce cell Apoptosis in A549 by FACs analysis.

Keywords

Anticancer; Apoptosis; Benzofuran; Dipiperazine.

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