2. Academic Validation
  3. Deploying solid-phase synthesis to access thymine-containing nucleoside analogs that inhibit DNA repair nuclease SNM1A

Deploying solid-phase synthesis to access thymine-containing nucleoside analogs that inhibit DNA repair nuclease SNM1A

  • Org Biomol Chem. 2023 Jul 19;21(28):5873-5879. doi: 10.1039/d3ob00836c.
Christine A Arbour 1,  Ellen M Fay 2,  Joanna F McGouran 2,  Barbara Imperiali 1
Affiliations

Affiliations

  • 1 Department of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. imper@mit.edu.
  • 2 School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St., Dublin 2, Ireland.
PMID: 37417819 DOI: 10.1039/d3ob00836c
Abstract

Nucleoside analogs show useful bioactive properties. A versatile solid-phase synthesis that readily enables the diversification of thymine-containing nucleoside analogs is presented. The utility of the approach is demonstrated with the preparation of a library of compounds for analysis with SNM1A, a DNA damage repair Enzyme that contributes to cytotoxicity. This exploration provided the most promising nucleoside-derived inhibitor of SNM1A to date with an IC50 of 12.3 μM.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-155595
    SNM1A抑制剂
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z