2. Academic Validation
  3. circSLC25A13 acts as a ceRNA to regulate AML progression via miR-616-3p/ADCY2 axis

circSLC25A13 acts as a ceRNA to regulate AML progression via miR-616-3p/ADCY2 axis

  • Mol Carcinog. 2023 Jul 26. doi: 10.1002/mc.23598.
Wenwen Wei 1 2 3 4,  Jiajia Pan 1 2 3 4,  Jinghan Wang 1 2 3 4,  Shihui Mao 1 2 3 4,  Yu Qian 1 2 3 4,  Xiangjie Lin 1 2 3 4,  Qing Ling 1 2 3 4,  Wenle Ye 1 2 3 4,  Yutong Zhou 1 2 3 4,  Yanchun Zhao 1 2 3 4,  Jiansong Huang 1 2 3 4,  Xin Huang 1 2 3 4,  Zhixin Ma 5,  Huanping Wang 1 2 3 4,  Chenying Li 1 2 3 4,  Jie Sun 1 2 3 4,  Jie Jin 1 2 3 4 6
Affiliations

Affiliations

  • 1 Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
  • 2 Zhejiang Provincial Key Laboratory of Hematologic Malignancy, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
  • 3 Zhejiang Provincial Clinical Research Center for Hematological Disorders, Hangzhou, Zhejiang, People's Republic of China.
  • 4 Zhejiang University Cancer Center, Hangzhou, Zhejiang, People's Republic of China.
  • 5 Department of Laboratorial Medicine, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
  • 6 Jinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong, People's Republic of China.
PMID: 37493101 DOI: 10.1002/mc.23598
Abstract

Circular RNAs (circRNAs), a type of endogenous noncoding RNA (ncRNA), exert vital roles in leukemia progression and are promising prognostic factors. Here, we report a novel circRNA, circSLC25A13 (hsa_circ_0081188), which was increased in acute myeloid leukemia (AML) patients with poor overall survival (OS) comparing to patients with good prognosis. Knockdown of circSLC25A13 in AML cells inhibited proliferation and increased cell Apoptosis in vitro and in vivo. Enhanced circSLC25A13 expression promoted the survival of AML cells. Mechanistically, circSLC25A13 played as a MicroRNA sponge of miR-616-3p, which inhibited the expression of Adenylate Cyclase 2 (ADCY2). Downregulation of miR-616-3p and overexpression of ADCY2 partially rescued circSLC25A13 deficient induced cell growth arrest. In summary, through competitive absorption of miR-616-3p and thereby upregulating ADCY2 expression, circSLC25A13 promoted AML progression. Moreover, circSLC25A13 may represent a potential novel biomarker for the prognosis of AML and offer a potential therapeutic target for AML treatment.

Keywords

acute myeloid leukemia; circular RNA; prognosis.

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