2. Academic Validation
  3. CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety

CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety

  • Cell Discov. 2023 Sep 12;9(1):94. doi: 10.1038/s41421-023-00588-2.
Xiangjia Zhu # 1 2 3 4 5,  Jiaqi Meng # 6 7 8 9,  Chaofeng Han 10 11,  Qingfeng Wu 12 13 14 15,  Yu Du 6 7 8 9,  Jiao Qi 6 7 8 9,  Ling Wei 6 7 8 9,  Hao Li 6 7 8 9,  Wenwen He 6 7 8 9,  Keke Zhang 6 7 8 9,  Yi Lu 16 17 18 19
Affiliations

Affiliations

  • 1 Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China. zhuxiangjia1982@126.com.
  • 2 NHC Key Laboratory of Myopia, Fudan University, Shanghai, China. zhuxiangjia1982@126.com.
  • 3 Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China. zhuxiangjia1982@126.com.
  • 4 Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China. zhuxiangjia1982@126.com.
  • 5 State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China. zhuxiangjia1982@126.com.
  • 6 Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
  • 7 NHC Key Laboratory of Myopia, Fudan University, Shanghai, China.
  • 8 Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.
  • 9 Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China.
  • 10 Department of Histoembryology, Naval Medical University, Shanghai, China. hcf@immunol.org.
  • 11 Shanghai Key Laboratory of Cell Engineering, Naval Medical University, Shanghai, China. hcf@immunol.org.
  • 12 State Key Laboratory of Molecular Development Biology, Chinese Academy of Sciences, Beijing, China.
  • 13 Institute of Genetics and Developmental Biology, University of Chinese Academy of Sciences, Beijing, China.
  • 14 CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, China.
  • 15 Chinese Institute for Brain Research, Beijing, China.
  • 16 Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China. luyieent@163.com.
  • 17 NHC Key Laboratory of Myopia, Fudan University, Shanghai, China. luyieent@163.com.
  • 18 Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China. luyieent@163.com.
  • 19 Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China. luyieent@163.com.
  • # Contributed equally.
PMID: 37699875 DOI: 10.1038/s41421-023-00588-2
Abstract

High myopia is a leading cause of blindness worldwide. It may lead to emotional defects that rely closely on the link between visual sensation and the central nervous system. However, the extent of the defects and its underlying mechanism remain unknown. Here, we report that highly myopic patients exhibit greater anxiety, accompanied by higher CC chemokine ligand 2 (CCL2) and monocyte levels in the blood. Similar findings are found in the mouse model of high myopia. Mechanistic evaluations using GFP-positive bone marrow chimeric mice, parabiotic mouse model, enhanced magnetic resonance imaging, etc., show that highly myopic visual stimulation increases CCL2 expression in eyes, aggravates monocyte/macrophage infiltration into eyes and brains, and disrupts blood-ocular barrier and blood-brain barrier of mice. Conversely, Ccl2-deficient highly myopic mice exhibit attenuated ocular and brain infiltration of monocytes/macrophages, reduced disruption of the blood-ocular barrier and blood-brain barrier, and less anxiety. Substantial alleviation of high myopia-related anxiety can also be achieved with the administration of CCL2-neutralizing Antibodies. Our results establish the association between high myopia and anxiety, and implicate the CCL2-mediated inflammatory pathogenesis as an underlying mechanism.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z