2. Academic Validation
  3. Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus

Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus

  • Sci Adv. 2023 Nov 3;9(44):eadi7337. doi: 10.1126/sciadv.adi7337.
Shuangbo Huang 1,  Jianzhao Chen 1,  Zhijuan Cui 1,  Kaidi Ma 1,  Deyuan Wu 1,  Jinxi Luo 1,  Fuyong Li,  Wenyu Xiong 1,  Sujuan Rao 1,  Quanhang Xiang 2,  Wei Shi 3,  Tongxing Song 4,  Jinping Deng 1,  Yulong Yin 1 5,  Chengquan Tan 1
Affiliations

Affiliations

  • 1 Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
  • 2 Department of Shenzhen Institute of Respiratory Diseases, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen 518000, China.
  • 3 Department of Obstetrics and Gynecology, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen 518000, China.
  • 4 Huazhong Agricultural University, College of Animal Science and Technology, Wuhan 430070, China.
  • 5 National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China.
PMID: 37922350 DOI: 10.1126/sciadv.adi7337
Abstract

Inflammation-associated Insulin resistance is a key trigger of gestational diabetes mellitus (GDM), but the underlying mechanisms and effective interventions remain unclear. Here, we report the association of placental inflammation (tumor necrosis factor-α) and abnormal maternal glucose metabolism in patients with GDM, and a high fermentable dietary fiber (HFDF; konjac) could reduce GDM development through gut flora-short-chain fatty acid-placental inflammation axis in GDM mouse model. Mechanistically, HFDF increases abundances of Lachnospiraceae and butyrate, reduces placental-derived inflammation by enhancing gut barrier and inhibiting the transfer of bacterial-derived lipopolysaccharide, and ultimately resists high-fat diet-induced Insulin resistance. Lachnospiraceae and butyrate have similar anti-GDM and anti-placental inflammation effects, and they can ameliorate placental function and pregnancy outcome effects probably by dampening placental immune dysfunction. These findings demonstrate the involvement of important placental inflammation-related mechanisms in the progression of GDM and the great potential of HFDFs to reduce susceptibility to GDM through gut-flora-placenta axis.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z