Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition

Affiliations

• 1 Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
• 2 Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
• 3 State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
• 4 State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.
• 5 Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, China.
• 6 Qilu hospital of Shandong University, Jinan, China.
• 7 Institute for Cancer Research, Shenzhen Bay Laboratory, Shenzhen, China.
• 8 Institute for Cancer Genetics, and Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, New York, NY, USA. wg8@cumc.columbia.edu.
• 9 State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China. renjiec@seu.edu.cn.
• 10 Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China. renjiec@seu.edu.cn.
• 11 School of Life Science, Beijing Institute of Technology, Beijing, China. renjiec@seu.edu.cn.
• 12 Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. renjiec@seu.edu.cn.
• 13 Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. zhushu@ustc.edu.cn.
• 14 Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. zhushu@ustc.edu.cn.
• 15 Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. chubo123@sdu.edu.cn.
• # Contributed equally.