2. Academic Validation
  3. Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora

Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora

  • J Nat Prod. 2024 Feb 23;87(2):266-275. doi: 10.1021/acs.jnatprod.3c00934.
Ayano Kobayashi 1,  Yohei Saito 1,  Katsunori Miyake 2,  Shuichi Fukuyoshi 1,  David J Newman 3,  Barry R O'Keefe 4 5,  Kuo-Hsiung Lee 6 7,  Kyoko Nakagawa-Goto 1 6
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
  • 2 Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.
  • 3 NIH Special Volunteer, Wayne, Pennsylvania 19087, United States.
  • 4 Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NCI at Frederick, Frederick, Maryland 21702-1201, United States.
  • 5 Molecular Targets Program, Center for Cancer Research, National Cancer Institute, NCI at Frederick, Frederick, Maryland 21702-1201, United States.
  • 6 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7568, United States.
  • 7 Chinese Medicine Research and Development Center, China Medical University and Hospital, 2 Yuh-Der Road, Taichung, 40447, Taiwan.
PMID: 38251859 DOI: 10.1021/acs.jnatprod.3c00934
Abstract

Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B-E (1-4)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid (5)], and four biphenyl derivatives [garcilatelibiphenyls A-D (6-9)] were newly isolated in a phytochemical study of a 50% MeOH/CH2Cl2 extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC50 values from 0.5 to 6.7 μM against all tested tumor cell lines.

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