2. Academic Validation
  3. Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets

Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets

  • Cell Mol Neurobiol. 2024 Feb 23;44(1):25. doi: 10.1007/s10571-024-01457-6.
Xinjuan Tian 1,  Xiang Li 1,  Mengtian Pan 1,  Lele Zixin Yang 2,  Yunman Li 3,  Weirong Fang 4
Affiliations

Affiliations

  • 1 School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Mailbox 207, Tongjiaxiang 24, Nanjing, Jiangsu, 210009, People's Republic of China.
  • 2 The Pennsylvania State University, State College, PA, 16801, USA.
  • 3 School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Mailbox 207, Tongjiaxiang 24, Nanjing, Jiangsu, 210009, People's Republic of China. liyunman@cpu.edu.cn.
  • 4 School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Mailbox 207, Tongjiaxiang 24, Nanjing, Jiangsu, 210009, People's Republic of China. weirongfang@cpu.edu.cn.
PMID: 38393376 DOI: 10.1007/s10571-024-01457-6
Abstract

Ferroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related to Ferroptosis. The mechanisms of Ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide metabolism, as well as glutathione and amino acid metabolism. What's more, the causal relationship between Ferroptosis and IS has been elucidated by several processes. The disruption of the blood-brain barrier, the release of excitatory Amino acids, and the inflammatory response after ischemic stroke all lead to the disorder of iron metabolism and the antioxidant system. Based on these statements, we reviewed the reported effects of compounds and drugs treating IS by modulating key molecules in Ferroptosis. Through detailed analysis of the roles of these key molecules, we have also more clearly demonstrated the essential effect of Ferroptosis in the occurrence of IS so as to provide new targets and ideas for the therapeutic targets of IS.

Keywords

Ferroptosis; Iron overload; Ischemic stroke; Lipid peroxidation.

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