2. Academic Validation
  3. CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits

CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits

  • Nat Commun. 2024 Apr 11;15(1):3128. doi: 10.1038/s41467-024-47492-1.
Annemart Koornneef # 1,  Kanika Vanshylla # 1,  Gijs Hardenberg 1,  Lucy Rutten 1,  Nika M Strokappe 1,  Jeroen Tolboom 1,  Jessica Vreugdenhil 1,  Karin Feddes-de Boer 1,  Aditya Perkasa 1,  Sven Blokland 1,  Judith A Burger 2,  Wei-Chiao Huang 3,  Jonathan F Lovell 3,  Danielle van Manen 1,  Rogier W Sanders 2,  Roland C Zahn 1,  Hanneke Schuitemaker 1,  Johannes P M Langedijk 4 5,  Frank Wegmann 6
Affiliations

Affiliations

  • 1 Janssen Vaccines & Prevention, Leiden, The Netherlands.
  • 2 Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.
  • 3 Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, USA.
  • 4 Janssen Vaccines & Prevention, Leiden, The Netherlands. hlangedijk@forge-bio.com.
  • 5 ForgeBio, Amsterdam, The Netherlands. hlangedijk@forge-bio.com.
  • 6 Janssen Vaccines & Prevention, Leiden, The Netherlands. frank.wegmann.1@gmail.com.
  • # Contributed equally.
PMID: 38605096 DOI: 10.1038/s41467-024-47492-1
Abstract

One of the strategies towards an effective HIV-1 vaccine is to elicit broadly neutralizing antibody responses that target the high HIV-1 Env diversity. Here, we present an HIV-1 vaccine candidate that consists of cobalt porphyrin-phospholipid (CoPoP) liposomes decorated with repaired and stabilized clade C HIV-1 Env trimers in a prefusion conformation. These particles exhibit high HIV-1 Env trimer decoration, serum stability and bind broadly neutralizing Antibodies. Three sequential immunizations of female rabbits with CoPoP liposomes displaying a different clade C HIV-1 gp140 trimer at each dosing generate high HIV-1 Env-specific antibody responses. Additionally, serum neutralization is detectable against 18 of 20 multiclade tier 2 HIV-1 strains. Furthermore, the peak antibody titers induced by CoPoP liposomes can be recalled by subsequent heterologous immunization with Ad26-encoded membrane-bound stabilized Env antigens. Hence, a CoPoP liposome-based HIV-1 vaccine that can generate cross-clade neutralizing antibody immunity could potentially be a component of an efficacious HIV-1 vaccine.

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