2. Academic Validation
  3. Antioxidant and anti-Alzheimer's disease activities of 1,8-cineole and its cyclodextrin inclusion complex

Antioxidant and anti-Alzheimer's disease activities of 1,8-cineole and its cyclodextrin inclusion complex

  • Biomed Pharmacother. 2024 Jun:175:116784. doi: 10.1016/j.biopha.2024.116784.
Xin Tan 1,  Rui Xu 1,  Ai-Pei Li 2,  Dan Li 1,  Yun Wang 1,  Qian Zhao 1,  Li-Ping Long 1,  Yu-Zhou Fan 1,  Chen-Xiao Zhao 1,  Yan Liu 3,  Sheng-Hong Li 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Southwestern Chinese Medicine Resources, and Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
  • 2 College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
  • 3 State Key Laboratory of Southwestern Chinese Medicine Resources, and Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China. Electronic address: liuyan@cdutcm.edu.cn.
  • 4 State Key Laboratory of Southwestern Chinese Medicine Resources, and Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: shli@cdutcm.edu.cn.
PMID: 38781865 DOI: 10.1016/j.biopha.2024.116784
Abstract

1,8-Cineole is a bicyclic monoterpene widely distributed in the essential oils of various medicinal Plants, and it exhibits significant anti-inflammatory and antioxidant activities. We aimed to investigate the therapeutic effect of 1,8-cineole on anti-Alzheimer's disease by using transgenic Caenorhabditis elegans models. Our studies demonstrated that 1,8-cineole significantly relieved Aβ1-42-induced paralysis and exhibited remarkable antioxidant and anti-Aβ1-42 aggregation activities in transgenic nematodes CL4176, CL2006 and CL2355. We developed a 1,8-cineole/cyclodextrin inclusion complex, displaying enhanced anti-paralysis, anti-Aβ aggregation and antioxidant activities compared to 1,8-cineole. In addition, we found 1,8-cineole treatment activated the SKN-1/Nrf-2 pathway and induced Autophagy in nematodes. Our results demonstrated the antioxidant and anti-Alzheimer's disease activities of 1,8-cineole, which provide a potential therapeutic approach for Alzheimer's disease.

Keywords

1; 8-Cineole; Anti-Alzheimer's disease activity; Anti-Aβ aggregation activity; Antioxidant activity; Caenorhabditis elegans; Cyclodextrin inclusion complex.

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