Genetic tracing uncovers the importance of epithelial-to-mesenchymal transition in small cell lung cancer chemotherapy resistance but not metastasis

Affiliations

• 1 School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
• 2 Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
• 3 School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
• 4 University of Chinese Academy of Sciences, Beijing, China.
• 5 Department of Medical Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
• 6 Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, China.
• 7 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
• 8 School of Life Science and Technology, ShanghaiTech University, Shanghai, China. zhoubin@sibs.ac.cn.
• 9 Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China. zhoubin@sibs.ac.cn.
• 10 School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang, China. zhoubin@sibs.ac.cn.
• 11 University of Chinese Academy of Sciences, Beijing, China. zhoubin@sibs.ac.cn.
• 12 School of Life Science and Technology, ShanghaiTech University, Shanghai, China. hbji@sibcb.ac.cn.
• 13 Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China. hbji@sibcb.ac.cn.
• 14 School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang, China. hbji@sibcb.ac.cn.
• 15 University of Chinese Academy of Sciences, Beijing, China. hbji@sibcb.ac.cn.
• # Contributed equally.