2. Academic Validation
  3. Bacterial c-di-GMP triggers metamorphosis of mussel larvae through a STING receptor

Bacterial c-di-GMP triggers metamorphosis of mussel larvae through a STING receptor

  • NPJ Biofilms Microbiomes. 2024 Jun 20;10(1):51. doi: 10.1038/s41522-024-00523-7.
Xiao-Meng Hu # 1 2,  Lihua Peng # 1 2,  Yuyi Wang 1 2,  Fan Ma 1 2,  Yu Tao 1 2,  Xiao Liang 3 4,  Jin-Long Yang 5 6
Affiliations

Affiliations

  • 1 International Research Center for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, China.
  • 2 Shanghai Collaborative Innovation Center for Cultivating Elite Breeds and Green-Culture of Aquaculture Animals, Shanghai, 201306, China.
  • 3 International Research Center for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, China. x-liang@shou.edu.cn.
  • 4 Shanghai Collaborative Innovation Center for Cultivating Elite Breeds and Green-Culture of Aquaculture Animals, Shanghai, 201306, China. x-liang@shou.edu.cn.
  • 5 International Research Center for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, China. jlyang@shou.edu.cn.
  • 6 Shanghai Collaborative Innovation Center for Cultivating Elite Breeds and Green-Culture of Aquaculture Animals, Shanghai, 201306, China. jlyang@shou.edu.cn.
  • # Contributed equally.
PMID: 38902226 DOI: 10.1038/s41522-024-00523-7
Abstract

Bacteria induced metamorphosis observed in nearly all marine invertebrates. However, the mechanism of bacteria regulating the larvae-juvenile metamorphosis remains unknown. Here, we test the hypothesis that c-di-GMP, a ubiquitous Bacterial second-messenger molecule, directly triggers the mollusc Mytilus coruscus larval metamorphosis via the stimulator of interferon genes (STING) receptor. We determined that the deletion of c-di-GMP synthesis genes resulted in reduced c-di-GMP levels and biofilm-inducing activity on larval metamorphosis, accompanied by alterations in extracellular polymeric substances. Additionally, c-di-GMP extracted from tested varying marine bacteria all exhibited inducing activity on larval metamorphosis. Simultaneously, through pharmacological and molecular experiments, we demonstrated that M. coruscus STING (McSTING) participates in larval metamorphosis by binding with c-di-GMP. Our findings reveal that new role of Bacterial c-di-GMP that triggers mussel larval metamorphosis transition, and extend knowledge in the interaction of bacteria and host development in marine ecosystems.

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