2. Academic Validation
  3. Activated STING-containing R-EVs from iPSC-derived MSCs promote antitumor immunity

Activated STING-containing R-EVs from iPSC-derived MSCs promote antitumor immunity

  • Cancer Lett. 2024 Jun 22:597:217081. doi: 10.1016/j.canlet.2024.217081.
Linxia Qian 1,  Zhonghan Zhang 2,  Ruhua Zhang 2,  Xueping Zheng 2,  Beibei Xiao 2,  Xiaomin Zhang 2,  Yuanzhong Wu 2,  Yang Chen 3,  Xingding Zhang 4,  Penghui Zhou 2,  Qingling Fu 5,  Tiebang Kang 6,  Ying Gao 7
Affiliations

Affiliations

  • 1 State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, China; School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, Guangdong, China.
  • 2 State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, China.
  • 3 Departments of Endodontics, Stomatological Hospital, Southern Medical University, Guangzhou, 510000, Guangdong, China.
  • 4 School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, 518107, Guangdong, China.
  • 5 Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China. Electronic address: fuqingl@mail.sysu.edu.cn.
  • 6 State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, China. Electronic address: kangtb@sysucc.org.cn.
  • 7 State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, China. Electronic address: gaoying@sysucc.org.cn.
PMID: 38909776 DOI: 10.1016/j.canlet.2024.217081
Abstract

We recently revealed that activated STING is secreted into RAB22A-induced extracellular vesicles (R-EVs) and promotes antitumor immunity in Cancer cells. Whether mesenchymal stem cell (MSC)-derived R-EVs containing activated STING can be used as a novel antitumor immunotherapy remains unclear, as MSC-derived EVs are promising cell-free therapeutics due to their superior biocompatibility and safety, as well as low immunogenicity. Here, we report that induced pluripotent stem cell (iPSC)-derived MSCs can generate R-EVs with a size and mechanism of formation that are similar to those of R-EVs produced from Cancer cells. Furthermore, these MSC-derived R-EVs containing activated STING induced IFNβ expression in recipient THP-1 monocytes and antitumor immunity in mice. Our findings reveal that the use of MSC-derived R-EVs containing activated STING is a promising cell-free strategy for antitumor immunity.

Keywords

Antitumor immunity; Extracellular vesicles; Mesenchymal stem cells; RAB22A; Rafeesome; STING.

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