2. Academic Validation
  3. Intermittent Fasting Targets Osteocyte Neuropeptide Y to Relieve Osteoarthritis

Intermittent Fasting Targets Osteocyte Neuropeptide Y to Relieve Osteoarthritis

  • Adv Sci (Weinh). 2024 Jul 8:e2400196. doi: 10.1002/advs.202400196.
Yu-Xuan Qian 1 2,  Shan-Shan Rao 1 2,  Yi-Juan Tan 1 2,  Zun Wang 1 2,  Hao Yin 1 2,  Teng-Fei Wan 1 2,  Ze-Hui He 1 2,  Xin Wang 1 2,  Chun-Gu Hong 1 2,  Hai-Jin Zeng 1 2,  Yi Luo 1 2,  Yan-Xin Duan 1 2,  Hao Zhu 1 2,  Xin-Yue Hu 3,  Ling Zou 1 2,  Yan Zhang 1 4,  Bing-Bing Liu 5,  Zhen-Xing Wang 1 2,  Wei Du 1 2 6,  Chun-Yuan Chen 1 2 7,  Hui Xie 1 2 7
Affiliations

Affiliations

  • 1 Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • 2 Hunan Key Laboratory of Angmedicine, Changsha, Hunan, 410008, China.
  • 3 Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • 4 Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • 5 School of Computer Science and Engineering, Central South University, Changsha, Hunan, 410083, China.
  • 6 Department of Rehabilitation, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • 7 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
PMID: 38978353 DOI: 10.1002/advs.202400196
Abstract

Osteoarthritis is a highly prevalent progressive joint disease that still requires an optimal therapeutic approach. Intermittent fasting is an attractive dieting strategy for improving health. Here this study shows that intermittent fasting potently relieves medial meniscus (DMM)- or natural aging-induced osteoarthritic phenotypes. Osteocytes, the most abundant bone cells, secrete excess neuropeptide Y (NPY) during osteoarthritis, and this alteration can be altered by intermittent fasting. Both NPY and the NPY-abundant culture medium of osteocytes (OCY-CM) from osteoarthritic mice possess pro-inflammatory, pro-osteoclastic, and pro-neurite outgrowth effects, while OCY-CM from the intermittent fasting-treated osteoarthritic mice fails to induce significant stimulatory effects on inflammation, osteoclast formation, and neurite outgrowth. Depletion of osteocyte NPY significantly attenuates DMM-induced osteoarthritis and abolishes the benefits of intermittent fasting on osteoarthritis. This study suggests that osteocyte NPY is a key contributing factor in the pathogenesis of osteoarthritis and intermittent fasting represents a promising nonpharmacological antiosteoarthritis method by targeting osteocyte NPY.

Keywords

fasting; neuropeptide Y; osteoarthritis; therapeutics.

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