Berberine ameliorates vascular dysfunction by downregulating TMAO-endoplasmic reticulum stress pathway via gut microbiota in hypertension

Affiliations

• 1 The International Medical Department, Shenzhen Hospital, Southern Medical University, Shenzhen, China; Integrative Microecology Clinical Center, Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
• 2 Department of Geriatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
• 3 The International Medical Department, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
• 4 Department of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
• 5 Department of Geriatrics, Shenzhen Longhua District Central Hospital, Shenzhen, China.
• 6 Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
• 7 Integrative Microecology Clinical Center, Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease, Shenzhen Hospital, Southern Medical University, Shenzhen, China. Electronic address: yechen_fimmu@163.com.
• 8 National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address: liuyueheart@hotmail.com.
• 9 The International Medical Department, Shenzhen Hospital, Southern Medical University, Shenzhen, China; Integrative Microecology Clinical Center, Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease, Shenzhen Hospital, Southern Medical University, Shenzhen, China. Electronic address: chenl_sz@smu.edu.cn.