2. Academic Validation
  3. Anti-cancer effects of nitazoxanide in epithelial ovarian cancer in-vitro and in-vivo

Anti-cancer effects of nitazoxanide in epithelial ovarian cancer in-vitro and in-vivo

  • Chem Biol Interact. 2024 Sep 1:400:111176. doi: 10.1016/j.cbi.2024.111176.
Xiangqun Yang 1,  Zhenyan Liu 1,  Xin Wang 1,  Wenda Tian 1,  Taoyu Zhao 2,  Qiaoling Yang 1,  Wenliang Li 1,  Linlin Yang 3,  Hongying Yang 4,  Yue Jia 5
Affiliations

Affiliations

  • 1 Department of Gynecology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, 650118, PR China.
  • 2 Department of Obstetrics and Gynecology, Dehong Affiliated Hospital of Kunming Medical University, Dehong People's Hospital of Yunnan Province, Yunnan, 678400, PR China.
  • 3 Department of Gynecology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, 650118, PR China. Electronic address: YLL194900@sina.com.
  • 4 Department of Gynecology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, 650118, PR China. Electronic address: Yanghy913@126.com.
  • 5 Department of Gynecology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, 650118, PR China. Electronic address: kuailejy999@163.com.
PMID: 39084502 DOI: 10.1016/j.cbi.2024.111176
Abstract

Epithelial ovarian Cancer is one of the most lethal gynecologic malignancies and poses a considerable threat to women's health. Although the progression-free survival of patients has been prolonged with the application of anti-angiogenesis drugs and Poly (ADP-ribose) polymerases (PARP) inhibitors, overall survival has not substantially improved. Thus, new therapeutic strategies are essential for the treatment of ovarian Cancer. Nitazoxanide (NTZ), an FDA-approved Anti-parasitic drug, has garnered attention for its potential anti-cancer activity. However, the anti-tumor effects and possible underlying mechanisms of NTZ on ovarian Cancer remain unclear. In this study, we investigated the anti-tumor effects and the mechanism of NTZ on ovarian Cancer in vitro and in vivo. We found that NTZ inhibited the proliferation of A2780 and SKOV3 epithelial ovarian Cancer cells in a time- and concentration-dependent manner; Furthermore, NTZ suppressed the metastasis and invasion of A2780 and SKOV3 cells in vitro, correlating with the inhibition of epithelial-mesenchymal transition; Additionally, NTZ suppressed the Hippo/YAP/TAZ signaling pathway both in vitro and in vivo and demonstrated a good binding activity with core genes of Hippo pathway, including Hippo, YAP, TAZ, LATS1, and LATS2. Oral administration of NTZ inhibited tumor growth in xenograft ovarian Cancer mice models without causing considerable damage to major organs. Overall, these data suggest that NTZ has therapeutic potential for treating epithelial ovarian Cancer.

Keywords

Epithelial ovarian cancer; Hippo/YAP/TAZ signaling pathway; Metastasis; Nitazoxanide; Proliferation.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z