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  3. Stromal KITL/SCF promotes pancreas tissue homeostasis and restrains tumor progression

Stromal KITL/SCF promotes pancreas tissue homeostasis and restrains tumor progression

  • bioRxiv. 2024 Jul 30:2024.07.29.605485. doi: 10.1101/2024.07.29.605485.
M Kathrina Oñate 1 2,  Chet Oon 1 2,  Sohinee Bhattacharyya 1 2,  Vivien Low 1,  Canping Chen 3,  Xiaofan Zhao 3,  Ziqiao Yan 4,  Yan Hang 4 5,  Seung K Kim 4 5 6 7,  Zheng Xia 3,  Mara H Sherman 1 2
Affiliations

Affiliations

  • 1 Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • 2 Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon.
  • 3 Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon.
  • 4 Department of Developmental Biology, Stanford University School of Medicine, Stanford, California.
  • 5 Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, California.
  • 6 Department of Medicine, Stanford University School of Medicine, Stanford, California.
  • 7 Department of Pediatrics, Stanford University School of Medicine, Stanford, California.
PMID: 39131374 DOI: 10.1101/2024.07.29.605485
Abstract

Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to immune and non-immune stromal elements enable loss of homeostasis during tumor evolution. The precise mechanisms by which normal stromal cell states limit tissue plasticity and tumorigenesis, and which are lost during tumor progression, remain largely unknown. Here we show that healthy pancreatic mesenchyme expresses the paracrine signaling molecule KITL, also known as stem cell factor, and identify loss of stromal KITL during tumorigenesis as tumor-promoting. Genetic inhibition of mesenchymal KITL in the contexts of homeostasis, injury, and Cancer together indicate a role for KITL signaling in maintenance of pancreas tissue architecture, such that loss of the stromal KITL pool increased tumor growth and reduced survival of tumor-bearing mice. Together, these findings implicate loss of mesenchymal KITL as a mechanism for establishing a tumor-permissive microenvironment.

Keywords

mesenchymal cells; pancreatic cancer; paracrine signaling; tissue plasticity.

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