2. Academic Validation
  3. Bergenin protects against osteoarthritis by inhibiting STAT3, NF-κB and Jun pathways and suppressing osteoclastogenesis

Bergenin protects against osteoarthritis by inhibiting STAT3, NF-κB and Jun pathways and suppressing osteoclastogenesis

  • Sci Rep. 2024 Aug 31;14(1):20292. doi: 10.1038/s41598-024-71259-9.
Zhiwei Zhang # 1 2 3,  Bo Li # 1 2 3,  Shuqin Wu # 4,  Yuxin Yang 4,  Binkang Wu 1 2 3,  Qi Lai 1 2 3,  Fuchong Lai 1 2 3,  Fengbo Mo 1 2 3,  Yufei Zhong 4,  Song Wang 5 6 7,  Runsheng Guo 8 9 10,  Bin Zhang 11 12 13
Affiliations

Affiliations

  • 1 Department of Orthopedic Hospital, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China.
  • 2 Department of Sports Medicine of Orthopedic Hospital, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China.
  • 3 Artificial Joints Engineering and Technology Research Center of Jiangxi Province, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China.
  • 4 Faculty of Jiangxi Medical College, Donghu District, Nanchang University, No.461 Bayi Road, Nanchang, 330006, Jiangxi, China.
  • 5 Department of Orthopedic Hospital, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. ndyfy10323@ncu.edu.cn.
  • 6 Department of Sports Medicine of Orthopedic Hospital, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. ndyfy10323@ncu.edu.cn.
  • 7 Artificial Joints Engineering and Technology Research Center of Jiangxi Province, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. ndyfy10323@ncu.edu.cn.
  • 8 Department of Orthopedic Hospital, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. ndyfy02752@ncu.edu.cn.
  • 9 Department of Sports Medicine of Orthopedic Hospital, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. ndyfy02752@ncu.edu.cn.
  • 10 Artificial Joints Engineering and Technology Research Center of Jiangxi Province, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. ndyfy02752@ncu.edu.cn.
  • 11 Department of Orthopedic Hospital, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. ndyfy01354@ncu.edu.cn.
  • 12 Department of Sports Medicine of Orthopedic Hospital, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. ndyfy01354@ncu.edu.cn.
  • 13 Artificial Joints Engineering and Technology Research Center of Jiangxi Province, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. ndyfy01354@ncu.edu.cn.
  • # Contributed equally.
PMID: 39217193 DOI: 10.1038/s41598-024-71259-9
Abstract

Osteoarthritis (OA) is a chronic degenerative disease characterized by articular cartilage destruction and subchondral bone reconstruction in the early stages. Bergenin (Ber) is a cytoprotective polyphenol found in many medicinal Plants. It has been proven to have anti-inflammatory, antioxidant, and Other biological activities, which may reveal its potential role in the treatment of OA. This study aimed to determine the potential efficacy of Ber in treating OA and explore the possible underlying mechanism through network pharmacology and validation experiments. The potential co-targets and processes of Ber and OA were predicted by using network pharmacology, including a Venn diagram for intersection targets, a protein‒protein interaction (PPI) network to obtain key potential targets, and GO and KEGG pathway enrichment to reveal the probable mechanism of action of Ber on OA. Subsequently, validation experiments were carried out to investigate the effects and mechanisms of Ber in treating OA in vitro and vivo. Ber suppressed IL-1β-induced chondrocyte Apoptosis and extracellular matrix catabolism by inhibiting the STAT3, NF-κB and Jun signalling pathway in vitro. Furthermore, Ber suppressed the expression of osteoclast marker genes and RANKL-induced osteoclastogenesis. Ber alleviated the progression of OA in DMM-induced OA mice model. These results demonstrated the protective efficacy and potential mechanisms of Ber against OA, which suggested that Ber could be adopted as a potential therapeutic agent for treating OA.

Keywords

Bergenin; Jun; NF-κB; Osteoarthritis; Osteoclastogenesis; STAT3.

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