2. Academic Validation
  3. Evodiamine inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells via the SRC/ERBB2-mediated MAPK/ERK signaling pathway

Evodiamine inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells via the SRC/ERBB2-mediated MAPK/ERK signaling pathway

  • J Transl Med. 2024 Sep 27;22(1):859. doi: 10.1186/s12967-024-05656-z.
Jie Liu # 1,  Lan He # 2,  Wenqing Zhang 1,  Yinggang Tang 1,  Jingying Fan 1 3,  Yingchun He 4 5 6
Affiliations

Affiliations

  • 1 Hunan University of Chinese Medicine, Changsha, 410208, China.
  • 2 The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China.
  • 3 Hunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha, 410208, China.
  • 4 Hunan University of Chinese Medicine, Changsha, 410208, China. heyingchun@hnucm.edu.cn.
  • 5 Hunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha, 410208, China. heyingchun@hnucm.edu.cn.
  • 6 Hunan Provincial Key Lab for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China. heyingchun@hnucm.edu.cn.
  • # Contributed equally.
PMID: 39334374 DOI: 10.1186/s12967-024-05656-z
Abstract

This study aimed to investigate the effect and potential mechanism of evodiamine (EVO) on proliferation and Apoptosis of nasopharyngeal carcinoma (NPC) cells. EVO inhibited proliferation, blocked cell cycle progression, and induced Apoptosis of NPC cells. There are 27 known anti-NPC targets of EVO, of which eight are core targets, namely Src, ERBB2, STAT3, MAPK8, NOS3, CXCL8, APP, and HDAC1. Molecular docking analysis showed that the binding of EVO with its key targets (Src, ERBB2) was good. EVO also reduced the expression of Src and ERBB2, the key proteins p-MEK and p-ERK1/2 of the MAPK/ERK signaling pathway, and the downstream proteins PCNA and XIAP. EVO inhibited the growth of NPC xenografts in nude mice and reduced the expression levels of Src, ERBB2, ERK1/2, p-ERK1/2, PCNA and XIAP in NPC tissue. When the MAPK/ERK signaling pathway was activated by epidermal growth factor (EGF), the expression levels of PCNA and XIAP increased, the cell proliferation index increased, and the Apoptosis rate decreased in the EGF + EVO treatment group compared to treatment with EVO alone. These changes indicated that the inhibitory effect of EVO on proliferation and Apoptosis of NPC cells was related to the down-regulation of Src and ERBB2 expression, and further inhibition of the MAPK/ERK signaling pathway.

Keywords

ERBB2; Evodiamine; MAPK/ERK signaling pathway; Nasopharyngeal carcinoma; SRC.

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