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  3. Integrating larval zebrafish model and network pharmacology for screening and identification of edible herbs with therapeutic potential for MAFLD: A promising drug Smilax glabra Roxb

Integrating larval zebrafish model and network pharmacology for screening and identification of edible herbs with therapeutic potential for MAFLD: A promising drug Smilax glabra Roxb

  • Food Chem. 2025 Feb 1;464(Pt 1):141470. doi: 10.1016/j.foodchem.2024.141470.
Yinjuan Xiong 1,  Xixuan Huang 1,  Yuxin Li 1,  Yukang Nie 1,  Haodong Yu 1,  Yaqi Shi 1,  Jiajie Xue 1,  Zhehui Ji 1,  Keming Rong 2,  Xuezhen Zhang 3
Affiliations

Affiliations

  • 1 College of Fisheries, Huazhong Agricultural University, Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Hubei Provincial Engineering Laboratory for Pond Aquaculture, Wuhan 430070, China; Hubei Hongshan Laboratory, Wuhan 430070, China.
  • 2 Research Institute of Huanong-Tianchen, Wuhan 430070, China.
  • 3 College of Fisheries, Huazhong Agricultural University, Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Hubei Provincial Engineering Laboratory for Pond Aquaculture, Wuhan 430070, China; Hubei Hongshan Laboratory, Wuhan 430070, China; Research Institute of Huanong-Tianchen, Wuhan 430070, China. Electronic address: xuezhen@mail.hzau.edu.cn.
PMID: 39406145 DOI: 10.1016/j.foodchem.2024.141470
Abstract

Metabolic-associated fatty liver disease (MAFLD) is becoming a prevalent chronic liver disease. Many medicinal and edible herbs exhibit remarkable biological activities in ameliorating MAFLD but lack a comprehensive assessment of their therapeutic efficacy. This study determined total phenolic and flavonoid contents and in vitro antioxidant properties of 34 edible herbs. Smilax glabra Roxb. (SGR), Coreopsis tinctoria Nutt., and Smilax china L. were obtained with the best bioactivity and antioxidant capacity. The high-cholesterol diet-induced larval zebrafish model was established to compare the anti-MAFLD activity of the three herb extracts mentioned above. In vivo experiments revealed that SGR intervention significantly decreased lipid accumulation, alleviated oxidative stress, and modulated intestinal microbiota composition in zebrafish. Furthermore, three potential active components in SGR and their possible mechanisms were explored through network pharmacology and molecular docking. Our study suggested that SGR is a potential candidate for developing new drugs or dietary supplements for MAFLD therapy.

Keywords

Active compounds; Edible herb; Metabolism-associated fatty liver disease (MAFLD); Network pharmacology; Smilax glabra Roxb.; Zebrafish.

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