2. Academic Validation
  3. A novel biomimetic nanovesicle containing caffeic acid-coupled carbon quantum dots for the the treatment of Alzheimer's disease via nasal administration

A novel biomimetic nanovesicle containing caffeic acid-coupled carbon quantum dots for the the treatment of Alzheimer's disease via nasal administration

  • J Nanobiotechnology. 2024 Oct 19;22(1):642. doi: 10.1186/s12951-024-02912-8.
Yu Hu # 1 2,  Jingwen Cui 3,  Junpeng Sun 4,  Xiaobang Liu 4,  Shuang Gao 1 2,  Xifan Mei # 5,  Chao Wu # 6 7,  He Tian # 8 9
Affiliations

Affiliations

  • 1 School of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
  • 2 Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
  • 3 The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
  • 4 Pharmacy School, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
  • 5 Liaoning Vocational College of Medicine, Shenyang, Liaoning, 110101, China. meixifan@jzmu.edu.cn.
  • 6 Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. wuchao@jzmu.edu.cn.
  • 7 Pharmacy School, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. wuchao@jzmu.edu.cn.
  • 8 School of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. tianhe@jzmu.edu.cn.
  • 9 Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. tianhe@jzmu.edu.cn.
  • # Contributed equally.
PMID: 39425199 DOI: 10.1186/s12951-024-02912-8
Abstract

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by progressive cognitive and physical impairment. Neuroinflammation is related to AD, and the misfolding and aggregation of amyloid protein in the brain creates an inflammatory microenvironment. Microglia are the predominant contributors to neuroinflammation, and abnormal activation of microglia induces the release of a large amount of inflammatory factors, promotes neuronal Apoptosis, and leads to cognitive impairment. In this study, we used microglial membranes containing caffeic acid-coupled carbon quantum dots to prepare a novel biomimetic nanocapsule (CDs-CA-MGs) for the treatment of AD. The application of CDs-CA-MGs via nasal administration can bypass the blood‒brain barrier (BBB) and directly target the site of inflammation. After treatment with CDs-CA-MGs, AD mice showed reduced inflammation in the brain, decreased neuronal Apoptosis, and significantly improved learning and memory abilities. In addition, CDs-CA-MGs affect inflammation-related JAK-STAT and Toll-like Receptor signaling pathways in AD mice. CDs-CA-MGs significantly downregulated interleukins (IL-1β and IL-6) and tumor necrosis factor (TNF-α). This finding suggested that CDs-CA-MGs may improve cognitive impairment by modulating inflammatory responses. In conclusion, the use of CDs-CA-MGs provides a possible therapeutic strategy for the treatment of AD.

Keywords

Alzheimer’s disease; Caffeic acid; Carbon quantum dots; Microglia; Neuroinflammation.

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