2. Academic Validation
  3. Size-dependent translocation and lymphatic transportation of polymeric nanocarriers post intraperitoneal administration

Size-dependent translocation and lymphatic transportation of polymeric nanocarriers post intraperitoneal administration

  • J Control Release. 2024 Dec:376:553-565. doi: 10.1016/j.jconrel.2024.10.032.
Yifan Cai 1,  Zichen Zhang 1,  Chang Liu 1,  Zongguang Tai 2,  Quangang Zhu 2,  Jianping Qi 3,  Yi Lu 4,  Zhongjian Chen 5,  Wei Wu 6,  Haisheng He 7
Affiliations

Affiliations

  • 1 School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.
  • 2 Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.
  • 3 School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China; Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.
  • 4 School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China; Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China; Fudan Zhangjiang Institute, Shanghai 201203, China.
  • 5 Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China. Electronic address: aajian818@163.com.
  • 6 School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China; Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China; Fudan Zhangjiang Institute, Shanghai 201203, China; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China. Electronic address: wuwei@shmu.edu.cn.
  • 7 School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China. Electronic address: he_haisheng@fudan.edu.cn.
PMID: 39427777 DOI: 10.1016/j.jconrel.2024.10.032
Abstract

Intraperitoneal (i.p.) administered nanomedicine has been widely applied in the clinical treatment of intra-abdominal diseases and preclinical pharmacological investigations. However, current understandings about the in vivo fate of i.p.-administered drug remains controversial owing to lack of reliable investigation tools. This work presents a nanoparticle-labeling strategy based on aggregation-caused quenching (ACQ) probes in the second near-infrared (NIR-II) window, which can eliminate the interference of unbound probes and allow for non-invasive tracking of nanoparticles in deep tissues. Our results strongly evidence a size-dependent absorption and biodistribution of the i.p.-administered polymeric nanocarriers (PNs) with particle sizes ranging from 30 to 1000 nm both in vivo and ex vivo, and moreover provide a clear visualization of lymphatic transportation and lymph node retention of integral PNs. Importantly, our findings suggest that small particles (≤30 nm) are favorable in systemic therapies due to their rapid absorption and high concentration (>19 %ID mL-1) in circulation, while large particles (over 1000 nm) are meant for localized treatment of abdominal diseases. Besides, the high retention of 200 nm nanoparticles within lymph nodes indicates their promising role in Cancer vaccines and lymphatic diseases including lymph node metastasis.

Keywords

Aggregation-caused quenching; Intraperitoneal administration; Particle size; Polymeric nanocarrier; Second near-infrared; Translocation.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z