2. Academic Validation
  3. Biomimetic Nanomotors for Deep Ischemia Penetration and Ferroptosis Inhibition in Neuroprotective Therapy of Ischemic Stroke

Biomimetic Nanomotors for Deep Ischemia Penetration and Ferroptosis Inhibition in Neuroprotective Therapy of Ischemic Stroke

  • Adv Mater. 2024 Nov 26:e2409176. doi: 10.1002/adma.202409176.
Rui Wang 1,  Weimin Nie 1,  Xin Yan 1,  Kuankuan Luo 1,  Qi Zhang 1,  Tao Wang 1,  Enhao Lu 1,  Yiting Chen 1,  Yu Luo 1,  Zhiwen Zhang 1,  He Wang 2 3,  Jing Zhao 4 5,  Xianyi Sha 1 6
Affiliations

Affiliations

  • 1 Department of Pharmaceutics, School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery (Ministry of Education), Shanghai, 201203, China.
  • 2 Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Ministry of Education), Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200 433, China.
  • 3 Department of Radiology, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, 200 081, China.
  • 4 Department of Neurology, Minhang Hospital, Fudan University, Shanghai, 201 102, China.
  • 5 Institute of Healthy Yangtze River Delta, Shanghai Jiao Tong University, Shanghai, 200 030, China.
  • 6 Quzhou Fudan Institute, Quzhou, 324 002, China.
PMID: 39600046 DOI: 10.1002/adma.202409176
Abstract

Nerve injury represents the primary reason of mortality and disability in ischemic stroke, but effective drug delivery to the region of cerebral ischemia and hypoxia poses a significant challenge in neuroprotective treatment. To address these clinical challenges, a biomimetic nanomotor, Pt@LF is designed, to facilitate deep delivery of neuroprotective agents and inhibit Ferroptosis in ischemic stroke. Pt@LF traverses the blood-brain barrier (BBB) and penetrates into deep cerebral ischemic-hypoxic areas due to the active targeting capacity of apo-lactoferrin (Apo-LF) and the self-propelling motion properties of nanomotors. Subsequently, Pt@LF loosens thrombus and alleviates the "no reflow" phenomenon via mechanical thrombolysis. Thanks to the various enzyme-like abilities and multi-target Ferroptosis inhibition capability, Pt@LF ameliorates the inflammatory microenvironment and rescues dying neurons. In conclusion, Pt@LF demonstrates efficiently deep penetration and neuroprotective effects in vitro and vivo. And this study provides a promising therapeutic platform for the treatment of ischemic stroke.

Keywords

ferroptosis; ischemic stroke; nanomotors; neuroprotection; no reflow phenomenon.

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