2. Academic Validation
  3. Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies

Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies

  • Int Immunopharmacol. 2025 Jan 10:144:113695. doi: 10.1016/j.intimp.2024.113695.
Li Yin 1,  Zeju He 2,  Yong Fan 1,  Zexuan Niu 1,  Longtao Yao 1,  Sheyuan Ding 2,  Jihang Chen 2,  Qiong Zhang 3,  Yu Tong 4,  Qing Bi 5,  Li Cao 6
Affiliations

Affiliations

  • 1 Department of Sports Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang Province 325000, China; Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Institute of Sports Medicine and Osteoarthropathy of Hangzhou Medical College, Hangzhou, Zhejiang 310000, China.
  • 2 Department of Sports Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Institute of Sports Medicine and Osteoarthropathy of Hangzhou Medical College, Hangzhou, Zhejiang 310000, China.
  • 3 Department of Nursing, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China.
  • 4 Department of Sports Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Institute of Sports Medicine and Osteoarthropathy of Hangzhou Medical College, Hangzhou, Zhejiang 310000, China. Electronic address: tongyulal@163.com.
  • 5 Department of Sports Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang Province 325000, China; Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Institute of Sports Medicine and Osteoarthropathy of Hangzhou Medical College, Hangzhou, Zhejiang 310000, China. Electronic address: bqzjsrmyy@163.com.
  • 6 Department of Sports Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310000, China; Institute of Sports Medicine and Osteoarthropathy of Hangzhou Medical College, Hangzhou, Zhejiang 310000, China. Electronic address: tommycaoli@126.com.
PMID: 39608176 DOI: 10.1016/j.intimp.2024.113695
Abstract

Osteoarthritis (OA) is a prevalent, degenerative joint disease that requires effective treatments to prevent its progression. Therefore, the development of novel therapeutic strategies to address this unmet clinical challenge is paramount. Marein (MA), the principal active compound of Coreopsis tinctoria Nutt, exhibits anti-inflammatory and anti-oxidant properties in various diseases, indicating its potential as a therapeutic agent for OA. In this study, we assessed the ability of marein to mitigate the inflammatory response in OA and reverse cartilage degradation. The results demonstrated that MA exerted a concentration -dependent effect (10, 25, 50 μM), facilitating the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2), reversing the suppression of nuclear factor kappa B (NF-κB) activation, and mitigating the inflammatory response, ultimately alleviating joint cartilage damage. In cellular assays, MA (10, 25, 50 μM) markedly decreased the expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), matrix metalloproteinase-13 (MMP-13) and a metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), simultaneously decreasing Reactive Oxygen Species production by enhancing Nrf2 nuclear translocation. Furthermore, in animal models, MA (50 μM) significantly improved knee joint cartilage damage and effectively reduced OA progression. Further studies are needed to determine the long-term safety and therapeutic potential of MA and to expand its application scope. Moreover, preclinical studies are required to evaluate the efficacy of MA in humans. Overall, MA is a promising therapeutic candidate and may be an effective treatment for patients with OA.

Keywords

Anti-inflammatory; IL-1β; Marein; Nrf2/HO-1/NF-κB; Osteoarthritis; ROS.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z