Discovery and optimization of tetrahydroacridine derivatives as a novel class of antibiotics against multidrug-resistant Gram-positive pathogens by targeting type I signal peptidase and disrupting bacterial membrane

Affiliations

• 1 School of Science, China Pharmaceutical University, Nanjing, 211198, China; School of Pharmacy, Shanxi Medical University, Taiyuan, 030001, China.
• 2 MOE Joint International Research Laboratory of Animal Health and Food Safety, Risk Assessment Center of Veterinary Drug Residue and Antimicrobial Resistance, Center for Veterinary Drug Research and Evaluation, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China; Sanya Institute of Nanjing Agricultural University, Nanjing Agricultural University, Sanya, 572025, China.
• 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, China.
• 4 School of Science, China Pharmaceutical University, Nanjing, 211198, China.
• 5 MOE Joint International Research Laboratory of Animal Health and Food Safety, Risk Assessment Center of Veterinary Drug Residue and Antimicrobial Resistance, Center for Veterinary Drug Research and Evaluation, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
• 6 School of Science, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: cpuzdy@163.com.
• 7 School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: 1520220087@cpu.edu.cn.
• 8 MOE Joint International Research Laboratory of Animal Health and Food Safety, Risk Assessment Center of Veterinary Drug Residue and Antimicrobial Resistance, Center for Veterinary Drug Research and Evaluation, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China; Sanya Institute of Nanjing Agricultural University, Nanjing Agricultural University, Sanya, 572025, China. Electronic address: jhuang@njau.edu.cn.