2. Academic Validation
  3. Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis

Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis

  • Cancer Biol Ther. 2025 Dec;26(1):2442556. doi: 10.1080/15384047.2024.2442556.
Shi-Ming Tan 1,  Lan Luo 2,  Yi-Fu He 3,  Wei Li 4,  Xin-Xing Wan 5
Affiliations

Affiliations

  • 1 Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, China.
  • 2 Department of Obstetrics and Gynecology, The Third Xiangya Hospital, Central South University, Changsha, China.
  • 3 Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha, China.
  • 4 Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, China.
  • 5 Department of Endocrinology, The Third Xiangya Hospital, Central South University, Changsha, China.
PMID: 39699276 DOI: 10.1080/15384047.2024.2442556
Abstract

Lung Cancer, one of the most prevalent tumors, remains a clinical challenge with a poor five-year survival rate. Daurisoline, a bis-benzylisoquinoline alkaloid derived from the traditional Chinese herb Menispermum dauricum, is known to suppress tumor growth effectively. However, its precise mechanism of action remains unclear. In this study, we demonstrate that Daurisoline targets glycolysis and reduces the protein level of HK2, thereby inhibiting lung Cancer progression. Mechanistic investigations reveal that Daurisoline directly binds to Akt and antagonizes the AKT-GSK3β-c-Myc-HK2 signaling axis. Furthermore, in an animal model, we validate the in vivo anti-tumor effect of Daurisoline without any observable side effects. Overall, our findings suggest that Daurisoline holds potential as an anti-tumor agent through its targeting of glycolysis.

Keywords

AKT; HK2; Lung cancer; daurisoline.

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