The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer

Affiliations

• 1 Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
• 2 Department of Urology and Department of Pathology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
• 3 Department of General Surgery and Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
• 4 Research Center for Complexity Sciences, Hangzhou Normal University, Hangzhou, China.
• 5 Department of Colorectal Surgery, Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
• 6 School of Life Sciences, Fudan University, Shanghai, China.
• 7 Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Hainan Provincial Clinical Research Center for Thalassemia, Department of Reproductive Medicine, Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
• 8 Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
• 9 Department of Gastrointestinal Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
• 10 Computational Structural Biology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
• 11 Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
• 12 Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
• 13 Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.
• 14 Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
• 15 Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.
• 16 Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
• 17 Department of Pharmacology and Moores Cancer Center, University of California,San Diego, San Diego, CA, USA.
• 18 Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. myliu@bio.ecnu.edu.cn.
• 19 International Center for Aging and Cancer, Hainan Medical University, Haikou, China. myliu@bio.ecnu.edu.cn.
• 20 Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. wqlu@bio.ecnu.edu.cn.
• 21 University Engineering Research Center of Oncolytic & Nanosystem Development, Guangxi, China. wqlu@bio.ecnu.edu.cn.
• # Contributed equally.