2. Academic Validation
  3. Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance

Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance

  • Lancet. 1976 May 8;1(7967):991-3. doi: 10.1016/s0140-6736(76)91863-8.
M G Bryant,  M M Polak,  I Modlin,  S R Bloom,  R H Albuquerque,  A G Pearse
PMID: 57443 DOI: 10.1016/s0140-6736(76)91863-8
Abstract

Vasoactive intestinal peptide (V.I.P.) has been found in high concentrations both in the gastrointestinal tract and, unexpectedly, in the central nervous system. Immunocytochemical studies have demonstrated V.I.P. in nerve-fibers. These findings challenge the concept of V.I.P. as a simple gastrointestinal hormone and suggest a possible neurotransmitter function.

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