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  2. Kijanimicin (Sch 25663), a novel antibiotic produced by Actinomadura kijaniata SCC 1256. Fermentation, isolation, characterization and biological properties

Kijanimicin (Sch 25663), a novel antibiotic produced by Actinomadura kijaniata SCC 1256. Fermentation, isolation, characterization and biological properties

  • J Antibiot (Tokyo). 1981 Sep;34(9):1101-6. doi: 10.7164/antibiotics.34.1101.
J A Waitz A C Horan M Kalyanpur B K Lee D Loebenberg J A Marquez G Miller M G Patel
Abstract

A novel Antibiotic complex has been isolated form the fermentation broth of a new species of Actinomadura, A. kijaniata SCC 1256. The complex was separated form the broth by a solvent extraction procedure and consists of 1 major component, designated kijanimicin, and 3 minor components. Kijanimicin was isolated form the complex by column chromatography and/or preparative high pressure liquid chromatography. Structurally the compound is a unique, large acid enol Antibiotic and possesses an unusual in vitro spectrum of activity against some Gram-positive and anaerobic Microorganisms. In vivo it has also shown interesting activity against malaria.

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