2. Academic Validation
  3. Anti-fertility activity and hormonal profile of trans-anethole in rats

Anti-fertility activity and hormonal profile of trans-anethole in rats

  • Indian J Physiol Pharmacol. 1995 Jan;39(1):63-7.
S K Dhar 1
Affiliations

Affiliation

  • 1 Pharmacology Division, Regional Research Laboratory, Jammu Tawi.
PMID: 7705873
Abstract

Trans-anethole was studied for antifertility activity in rats at dose levels of 50 mg, 70 mg and 80 mg/kg po. Dose-dependent activity was observed, a 100% anti-implantation activity being achieved at 80 mg/kg, po. The compound showed a significant estrogenic activity and did not possess anti-estrogenic, progestational, anti-progestational, androgenic or anti-androgenic activities. In an earlier study, the compound was found to be safe, its LD50 being more than 3000 mg/kg, po in mice.

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