2. Academic Validation
  3. Effect of [dl]-alpha-tocopherol on FeCl2-induced lipid peroxidation in rat amygdala

Effect of [dl]-alpha-tocopherol on FeCl2-induced lipid peroxidation in rat amygdala

  • Neurosci Lett. 1994 Oct 10;180(1):33-6. doi: 10.1016/0304-3940(94)90907-5.
W J Triggs 1,  L J Willmore
Affiliations

Affiliation

  • 1 Department of Neurology, University of Florida College of Medicine, Gainesville.
PMID: 7877756 DOI: 10.1016/0304-3940(94)90907-5
Abstract

Peroxidative injury of neural membrane lipids can be initiated by iron-containing blood products, chelated ferrous or ferric ions, and low valence iron in aqueous solution. Lipid peroxidation was measured following focal injection of 3 microliters of 100 mM FeCl2 into rat amygdala. Acute parenteral administration of [dl]-alpha-tocopherol as the alcohol limited the quantity of peroxidation products generated. These data suggest a potential role for alpha-tocopherol administration in limiting brain injury responses.

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