2. Academic Validation
  3. HL 752: a potent and long-acting antispasmodic agent

HL 752: a potent and long-acting antispasmodic agent

  • Bioorg Med Chem. 1997 Jul;5(7):1381-7. doi: 10.1016/s0968-0896(97)00067-9.
S Bal-Tembe 1,  D N Bhedi,  A K Mishra,  R Rajagopalan,  A V Ghate,  P Subbarayan,  N S Punekar,  A V Kulkarni
Affiliations

Affiliation

  • 1 Research Centre, Hoechst Marion Roussel Limited, L.B.S. Marg, Mulund, Bombay, India.
PMID: 9377098 DOI: 10.1016/s0968-0896(97)00067-9
Abstract

Ester analogues of methyl-2-(4-(2-piperidinoethoxy)benzoyl)-benzoate hydrochloride (pitofenone) (2) were prepared with an aim to find a more potent and metabolically stable antispasmodic compound. The compounds were evaluated for their in vitro and in vivo antispasmodic activity, and stability to in vitro enzymatic hydrolysis. Of the compounds synthesised, HL 752 (21) showed the most potent and long-lasting antispasmodic activity and was selected as the candidate for clinical development.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z