2. Academic Validation
  3. Torsemide inhibits aldosterone secretion in vitro

Torsemide inhibits aldosterone secretion in vitro

  • Life Sci. 1998;63(3):PL45-50. doi: 10.1016/s0024-3205(98)00265-3.
T L Goodfriend 1,  D L Ball,  W Oelkers,  V Bähr
Affiliations

Affiliation

  • 1 William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA. tgoodfri@facstaff.wisc.edu
PMID: 9698054 DOI: 10.1016/s0024-3205(98)00265-3
Abstract

Torsemide inhibited aldosterone secretion by adrenal cells from rats, cows, and guinea pigs stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone. Inhibitory concentrations for adrenal cells (micromolar) were comparable with those reported to inhibit ion transport in isolated renal tubules. Inhibition of aldosterone secretion could reduce kaliuresis, and that may explain why torsemide causes less kaliuresis than other diuretics.

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