2. Academic Validation
  3. Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare

Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare

  • Bioorg Med Chem Lett. 1998 Dec 15;8(24):3519-24. doi: 10.1016/s0960-894x(98)00644-1.
A H Banskota 1,  Y Tezuka,  L K Phung,  K Q Tran,  I Saiki,  Y Miwa,  T Taga,  S Kadota
Affiliations

Affiliation

  • 1 Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
PMID: 9934464 DOI: 10.1016/s0960-894x(98)00644-1
Abstract

Seven novel cycloartane-type Triterpenes were isolated from Combretum quadrangulare, and their structures were elucidated on the basis of spectral analysis. All these compounds were tested for their cytotoxicity against murine colon 26-L5 carcinoma cells. Methyl quadrangularate B (2) and methyl quadrangularate D (4) exhibited potent cytotoxicity having ED50 values 9.54 and 5.42 microM, respectively.

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