2. Apoptosis
  3. MDM-2/p53
  4. MDM2/4-p53-IN-1

MDM2/4-p53-IN-1 是一种有效的 MDM2-p53 和 MDM4-p53 抑制剂， 对 MDM2-p53 和 MDM4-p53 的 IC50 值分别为 35.9、57.4 nM。MDM2/4-p53-IN-1 显示出抗增殖活性。

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MDM2/4-p53-IN-1 Chemical Structure

MDM2/4-p53-IN-1 Chemical Structure

CAS No. : 3037300-57-2

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MDM2/4-p53-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MDM2/4-p53-IN-1 is a potent MDM2-p53 and MDM4-p53 inhibitor with IC50 values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity[1].

IC50 & Target

IC50: 35.9 nM (MDM2-p53); 57.4 nM (MDM4-p53)[1]
体外研究
(In Vitro)

MDM2/4-p53-IN-1 (compound 3f) (0-100 μM; 48-96 h) shows antiproliferative activity with IC50 values of 20.9, 14.7, 11.5, 12.4 μM for HCT116, SJSA-1, LNCaP, MCF-7 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MDM2/4-p53-IN-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HCT116, SJSA-1, LNCaP, MCF-7 cells
Concentration: 0-100 µM
Incubation Time: 48 h (HCT116), 72 h (MCF7), 96 h (SJSA-1, LNCaP)
Result: Showed antiproliferative activity with IC50 values of 20.9, 14.7, 11.5, 12.4 µM for HCT116, SJSA-1, LNCaP, MCF-7 cells, respectively.
分子量

609.46

Formula

C32H22Cl2N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MDM2/4-p53-IN-1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2/4-p53-IN-13037300-57-2MDM-2/p53U87MGSHSY-5Y cellsantiproliferativeanticancerInhibitorinhibitorinhibit

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