2. Apoptosis
  3. MDM-2/p53
  4. MDM2-IN-21

MDM2-IN-21 是一种有效的 MDM2 抑制剂。MDM2-IN-21 可用于癌症研究。

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MDM2-IN-21 Chemical Structure

MDM2-IN-21 Chemical Structure

CAS No. : 939981-88-1

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MDM2-IN-21 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MDM2-IN-21 is a potent MDM2 inhibitor. MDM2-IN-21 can be used for the research of cancer[1].

IC50 & Target

MDM2[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
1.2 μM
Compound: 2b
Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
[PMID: 24900694]
MDA-MB-435 IC50
4.2 μM
Compound: 2b
Cytotoxicity against human MDA-MB-435 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human MDA-MB-435 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay
[PMID: 24900694]
RKO IC50
0.5 μM
Compound: 2b
Cytotoxicity against human RKO cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human RKO cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
[PMID: 24900694]
SJSA-1 IC50
0.6 μM
Compound: 2b
Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
[PMID: 24900694]
SW480 IC50
2.7 μM
Compound: 2b
Cytotoxicity against human SW480 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human SW480 cells expressing p53 mutant assessed as cell viability after 5 days by MTT assay
[PMID: 24900694]
体外研究
(In Vitro)

The IC50 values of MDM2-IN-21 are 0.03 μM and 0.8 μM in homogeneous time resolved fluorescence (HTRF) assay and the wild-type p53 cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MDM2-IN-21 相关抗体:
分子量

607.61

Formula

C34H40Cl2N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MDM2-IN-21 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2-IN-21939981-88-1MDM-2/p53potentcancertumorHTRFwild-typep53Inhibitorinhibitorinhibit

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产品名称：
MDM2-IN-21
目录号：
HY-139458
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